| 173293 |
O17670 |
EYA1_CAEEL |
Eyes absent homolog 1 (EC 3.1.3.48) |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown results in severe lethal arrest at an early larval stage (PubMed:16154558). The pharyngeal structure is disorganized and the anterior tip is thinner (PubMed:16154558). The phenotype is more severe in a pax-6 (ju468) mutant background (PubMed:16154558). RNAi-mediated knockdown in L1 larvae causes a decrease in resistance to heat or oxidative stresses characterized by a reduced lifespan, reduced heat shock protein hsp-16.2 expression and increased reactive oxygen species (ROS) production (PubMed:25108328). {ECO:0000269|PubMed:16154558, ECO:0000269|PubMed:25108328}. |