| 173437 |
Q9TYV5 |
NSUN1_CAEEL |
26S rRNA (cytosine-C(5))-methyltransferase nsun-1 (EC 2.1.1.-) (5-methylcytosine rRNA methyltransferase nsun-1) (NOL1/NOP2/Sun domain family member 1) (RNA cytosine C(5)-methyltransferase nsun-1) (rRNA cytosine C(5)-methyltransferase nsun-1) |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown in L1 larvae results in sterility (PubMed:33283887). RNAi-mediated knockdown in adults results in reduced egg-laying (PubMed:33289480). RNAi-mediated knockdown from day 0 of adulthood or in the germline does not affect lifespan (PubMed:33289480). RNAi-mediated knockdown in somatic tissues reduces lifespan by 10% and reduces body length and results in morphological defects in the gonad leading to the production of no oocytes (PubMed:33289480). RNAi-mediated knockdown increases resistance to heat stress and increases the speed of locomotion (PubMed:33289480). RNAi-mediated knockdown disrupts the localization of the germline-specific protein gld-1, results in collagen deposition and increases cuticle permeability (PubMed:33289480). RNAi-mediated knockdown reduces the methylation of cytosine to 5-methylcytosine (m5C) in 26S rRNA (PubMed:33289480). RNAi-mediated knockdown does not affect the methylation of cytosine 2381 to 5-methylcytosine (m5C2381) in 26S rRNA (PubMed:33289480). {ECO:0000269|PubMed:33283887, ECO:0000269|PubMed:33289480}. |