| 173525 |
O44827 |
FGT1_CAEEL |
Facilitated glucose transporter protein 1 |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown of the protein causes reduced 2-deoxy-D-glucose uptake, glucose oxidation and glucose conversion to triglyceride; simultaneous knockout of daf-2 or age-1 causes further reductions. The lifespan in low glucose environment is extended by 20-25% after knockdown, with 7% extension in daf-2 mutant background and no significant extension in age-1 mutant background. Fat accumulation in intestinal cells is increased. Brood size and dauer formation are not affected. {ECO:0000269|PubMed:23826391, ECO:0000269|PubMed:24024580}. |