Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 173990
  • Symbol: fzo-1
  • Description: Transmembrane GTPase fzo-1
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Gene ID Entry Entry Name Protein Name Type Information
173990 Q23424 FZO1_CAEEL Transmembrane GTPase fzo-1 (EC 3.6.5.-) DISRUPTION PHENOTYPE RNAi-mediated knockdown results in fragmented mitochondria, most likely due to lack of fusion activity (PubMed:25190516, PubMed:33734301). RNAi-mediated knockdown in a moma-1 mutant background results in mitochondrial fragmentation (PubMed:21248201). In a drp-1 mutant background, partially restores some tubular mitochondria (PubMed:33734301). Upon acute heat stress, in a drp-1 mutant background, autophagosomes clustered at mitochondria are detected in the epidermis (PubMed:33734301). {ECO:0000269|PubMed:21248201, ECO:0000269|PubMed:25190516}.