Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 174019
  • Symbol: rbbp-5
  • Description: Retinoblastoma-binding protein homolog 5
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Gene ID Entry Entry Name Protein Name Type Information
174019 Q09309 RBBP5_CAEEL Retinoblastoma-binding protein homolog 5 DISRUPTION PHENOTYPE Strongly reduced di- and trimethylation at 'Lys-4' of histone H3 in embryos and adult germline stem cells. Mutants also display defects in egg laying and fertility with defective germ cell development. RNAi-mediated knockdown disrupts development of the ASE left (ASEL) neuron, causing it to adopt the ASE right (ASER) cell fate (PubMed:21698137). {ECO:0000269|PubMed:21455483, ECO:0000269|PubMed:21698137}.