| 174401 |
P90925 |
PH4H_CAEEL |
Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (EC 1.14.16.4) (Biogenic amine synthesis protein 2) (Phe-4-monooxygenase) (Tryptophan 5-monooxygenase) |
DISRUPTION PHENOTYPE |
Reduced L-phenylalanine hydroxylation. Lack of a yellow-orange pheomelanine-like pigment in the cuticle. Higher cuticle resistance to physical or chemical disintegration factors or oxidizing environments. Increase in superoxide dismutase activity. Increased life span. In a bli-3(e767) mutant background, growth arrest in early larval development, severe cuticle abnormalities with large blisters and increased superoxide dismutase activity. RNAi-mediated knockdown together with fah-1 RNAi partially rescues the impaired growth and fertility defects in the single fah-1 RNAi mutant (PubMed:18227072). {ECO:0000269|PubMed:18227072, ECO:0000269|PubMed:18460651}. |