Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 174447
  • Symbol: hlh-3
  • Description: Helix-loop-helix protein 3
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Gene ID Entry Entry Name Protein Name Type Information
174447 Q22717 HLH3_CAEEL Helix-loop-helix protein 3 DISRUPTION PHENOTYPE Egg-laying defective (PubMed:18586090). Reduced expression of the tryptophan hydroxylase tph-1 which leads to reduced production of the neurotransmitter serotonin in the hermaphrodite-specific motor neurons (HSN) (PubMed:18586090). Inappropriate lateral projection of HSN axons (PubMed:18586090). Lack of netrin receptor unc-40 expression in a subset of HSN and VC motor neurons (PubMed:18586090). RNAi-mediated knockdown prevents cell death of a subset of the serotonergic neurosecretory motor (NSM) neuron sister cells, and survival of NSM sister cells is increased in an hlh-2 mutant background (PubMed:12874127). {ECO:0000269|PubMed:12874127, ECO:0000269|PubMed:18586090}.