Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 174462
  • Symbol: let-23
  • Description: Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase
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Gene ID Entry Entry Name Protein Name Type Information
174462 P24348 LET23_CAEEL Receptor tyrosine-protein kinase let-23 (EC 2.7.10.1) (Lethal protein 23) DISRUPTION PHENOTYPE Larval lethality, lack of vulva formation, infertility and lack of male spicule formation (PubMed:2071015). RNAi-mediated knockdown causes sterility, a small decrease in the peak rate of sheath cell contractions and a delay in the onset of ovulatory contractions (PubMed:15194811). Restores normal pharyngeal pumping rate in 30 percent of animals overexpressing lin-3 (PubMed:17891142). {ECO:0000269|PubMed:15194811, ECO:0000269|PubMed:17891142, ECO:0000269|PubMed:2071015}.