| 174638 |
Q17958 |
PDC10_CAEEL |
Programmed cell death protein 10 homolog (Cerebral cavernous malformation protein 3) |
DISRUPTION PHENOTYPE |
Animals are sterile and develop slowly. Excretory canals are approximately 45% shorter and are characterized by a discontinuous and wider lumen, the presence of cysts and an increased number of canalicular vesicles which are swollen. These defects start during the L3 larval stage and become more severe when reaching adulthood. In addition, cdc-42 expression levels and activity are reduced along the excretory canal length. Animals have also a reduced distribution of Golgi and ER components along the excretory canals. {ECO:0000269|PubMed:25743393}. |