Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 175153
  • Symbol: nsun-5
  • Description: 26S rRNA (cytosine-C(5))-methyltransferase nsun-5
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Gene ID Entry Entry Name Protein Name Type Information
175153 Q9NAA7 NSUN5_CAEEL 26S rRNA (cytosine-C(5))-methyltransferase nsun-5 (EC 2.1.1.-) (5-methylcytosine rRNA methyltransferase nsun-5) (NOL1/NOP2/Sun domain family member 5) (RNA cytosine C(5)-methyltransferase nsun-5) (rRNA cytosine C(5)-methyltransferase nsun-5) DISRUPTION PHENOTYPE RNAi-mediated knockdown increases lifespan and stress resistance (PubMed:25635753). RNAi-mediated knockdown results in a higher frequency of gene products that arise as a consequence of increased ribosomal frameshifting in response to osmotic stress induced by high salt concentrations in adults (PubMed:30977983). RNAi-mediated knockdown does not result in fertility defects (PubMed:33283887). {ECO:0000269|PubMed:25635753, ECO:0000269|PubMed:30977983, ECO:0000269|PubMed:33283887}.