| 175167 |
Q8ITW8 |
NHR80_CAEEL |
Nuclear hormone receptor family member nhr-80 |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown causes a change in fatty acid composition, including an increase in saturated fatty acid 18:0 and decrease in unsaturated 18:1 (PubMed:16839188). In a fatty acid desaturase fat-6 mutant background, become thin, slow growing, reproductively inviable after 4 days, and accumulate very high levels of 18:0 saturated fatty acid (PubMed:16839188). In a fat-6 mutant background, also drastically reduces expression of fat-7 (PubMed:16839188). In either a fat-5 or fat-7 mutant background, accumulates high levels of 18:0 saturated fatty acid, but less so than in the fat-6 mutant background (PubMed:16839188). Significantly reduced lifespan in a glp-1 mutant background, but does not affect lifespan of wild type (PubMed:21423649). Knockdown in the first generation offspring (F1) of adults fed a high-fat diet prevents lipid accumulation (PubMed:35140229). {ECO:0000269|PubMed:16839188, ECO:0000269|PubMed:21423649, ECO:0000269|PubMed:35140229}. |