Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 175184
  • Symbol: mxl-2
  • Description: BHLH domain-containing protein
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Gene ID Entry Entry Name Protein Name Type Information
175184 Q9TZ70 MXL2_CAEEL Max-like protein homolog 2 DISRUPTION PHENOTYPE RNAi-mediated knockdown reduces lifespan and is further reduced on a daf-2 mutant background (PubMed:24699255). RNAi-mediated knockdown causes premature onset of polyglutamine-mediated paralysis (PubMed:24699255). RNAi-mediated knockdown reduces spore levels of the microsporidian pathogen N.parisii during infection, further reduced on an mdl-1 mutant background (PubMed:27402359). {ECO:0000269|PubMed:24699255, ECO:0000269|PubMed:27402359}.