Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 175788
  • Symbol: rcan-1
  • Description: Calcipressin-like protein
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Gene ID Entry Entry Name Protein Name Type Information
175788 P53806 RCANL_CAEEL Calcipressin-like protein (Down syndrome candidate region 1-like protein) (Regulator of calcineurin) DISRUPTION PHENOTYPE Slightly shorter body length as compared to wild-type (PubMed:27871170). Reduced calcium responses in AFD neurons upon a temperature increase from 16 to 20 degrees Celsius as compared to wild-type (PubMed:26232604). At 17 and 20 degrees Celsius displays cryophilic behavior, preferentially migrating towards colder regions (PubMed:26232604). RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in adult males (also known as the Lep phenotype) (PubMed:21408209). {ECO:0000269|PubMed:21408209, ECO:0000269|PubMed:26232604, ECO:0000269|PubMed:27871170}.