| 175852 |
G5EEH9 |
NUP98_CAEEL |
Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (CeNup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (CeNup96)] |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown results in embryonic lethality (PubMed:12937276, PubMed:28122936). Two-cell embryos appear to lack nuclei and pronuclei (PubMed:12937276). Also causes severe defects in mitosis (PubMed:22238360, PubMed:28122936). Chromosome condensation is severely impaired during prophase (PubMed:28122936). Centrosome assembly during prophase and prometaphase and their subsequent resolution are impaired which results from impaired nuclear import of hcp-4 (PubMed:28122936). Impaired sister chromatin segregation (PubMed:28122936). Loss of nucleoporin npp-5 localization to the nuclear membrane during interphase and to kinetochores during metaphase (PubMed:22238360). Irregular nuclear membrane distribution of nucleoporin npp-13 (PubMed:28122936). Mutants display P granule dispersion (PubMed:20335358). {ECO:0000269|PubMed:12937276, ECO:0000269|PubMed:20335358, ECO:0000269|PubMed:22238360, ECO:0000269|PubMed:28122936}. |