| 175910 |
Q11186 |
PLPL2_CAEEL |
Patanin-like phospholipase domain-containing protein atgl-1 (EC 3.1.1.3) (Adipose triglyceride lipase 1) |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown reduces stored lipid droplet hydrolysis during fasting resulting in retained/increased lipid droplets and there are also increased lipid droplets in the fed state (PubMed:24120942, PubMed:25202121). Suppresses fasting-induced oxygen consumption (PubMed:25202121). RNAi-mediated knockdown abrogates the increased fat loss and increased oxygen consumption rate observed in the hlh-11 ok2944 mutant (PubMed:33078707). RNAi-mediated knockdown also abrogates the increased fat loss observed following overexpression of flp-7 (PubMed:28128367, PubMed:33078707). Furthermore, RNAi-mediated knockdown reduces the induction of hsp-60, an indicator of mitochondrial stress following overexpression of either flp-7 or hlh-11 (PubMed:33078707). RNAi-mediated knockdown in aak-2 mutants improves the survival of dauer larvae (PubMed:19052547). RNAi-mediated knockdown in daf-2 constitutive dauer phase mutants results in enlarged lipid droplets possibly due to an accumulation of unhydrolyzed triglycerides (PubMed:26098762). {ECO:0000269|PubMed:19052547, ECO:0000269|PubMed:24120942, ECO:0000269|PubMed:25202121, ECO:0000269|PubMed:26098762, ECO:0000269|PubMed:28128367, ECO:0000269|PubMed:33078707}. |