Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 175913
  • Symbol: vps-16
  • Description: Vacuolar protein sorting-associated protein 16 homolog
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Gene ID Entry Entry Name Protein Name Type Information
175913 Q11182 VPS16_CAEEL Vacuolar protein sorting-associated protein 16 homolog DISRUPTION PHENOTYPE Viable with a reduced number of gut granules in the adult intestine (PubMed:15843430, PubMed:24501423). Embryos of these adults arrest in early development and lack gut granules (PubMed:15843430). Endosome/lysosome fusion defects in coelomocytes (PubMed:26783301). RNAi-mediated knockdown results in a reduced number of gut granules in embryonic intestinal cells (PubMed:24501423). RNAi-mediated knockdown results in defective endosome maturation with the accumulation of small vesicles near the gut lumen and large endosomes/lysosomes on the basal side of the cell (PubMed:25273556). {ECO:0000269|PubMed:15843430, ECO:0000269|PubMed:24501423, ECO:0000269|PubMed:25273556, ECO:0000269|PubMed:26783301}.