| 175971 |
Q20937 |
CNOT1_CAEEL |
CCR4-NOT transcription complex subunit let-711 (CCR4-associated factor let-711) (Lethal protein 711) (Negative regulator of transcription subunit 1 homolog) (NOT1) |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown results in sterility and the production of inviable embryos which are osmotically sensitive, exhibit nuclear rotation defects and irregular positioning of the mitotic spindle which is located towards the posterior or lateral cortex during anaphase (PubMed:23843623, PubMed:16971515). RNAi-mediated knockdown may also result in a reduced brood size and larval lethality (PubMed:23843623). RNAi-mediated knockdown disrupts the arrangement and differentiation of oocytes in the proximal region and as a result small oocyte-like cells arrange in several rows in the germline (PubMed:23843623). RNAi-mediated knockdown reduces the levels of ccf-1, but does not alter ccr-4 levels (PubMed:23843623). RNAi-mediated knockdown results in reduced global poly(A) tail deadenylation (PubMed:23843623). RNAi-mediated knockdown results in reduces degradation of nos-2 mRNA, impairs the recruitment of lsm-1 and decreases the number of patr-1-positive granules in somatic blastomeres (PubMed:18692039). {ECO:0000269|PubMed:16971515, ECO:0000269|PubMed:18692039, ECO:0000269|PubMed:23843623}. |