Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 176282
  • Symbol: lin-12
  • Description: lin-12/Notch intracellular domain
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Gene ID Entry Entry Name Protein Name Type Information
176282 P14585 LIN12_CAEEL Protein lin-12 (Abnormal cell lineage protein 12) (Notch-like protein lin-12) [Cleaved into: lin-12/Notch intracellular domain] DISRUPTION PHENOTYPE RNAi-mediated knockdown in cells of the pi uterine cell lineage results in impaired basement membrane mobility (PubMed:27661254). Knockdown on a glp-1 mutant background impairs octanol response when animals are shifted to the restrictive temperature (PubMed:21549604). {ECO:0000269|PubMed:21549604, ECO:0000269|PubMed:27661254}.