Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 176296
  • Symbol: ina-1
  • Description: Integrin alpha ina-1
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Gene ID Entry Entry Name Protein Name Type Information
176296 Q03600 INA1_CAEEL Integrin alpha ina-1 DISRUPTION PHENOTYPE RNAi-mediated knockdown in distal tip cell (DTC) causes DTC morphological and guidance defects such as precocious dorsal turns, a failure to reach the vulva and a bloated distal gonad (PubMed:19023419). Embryos at the comma, 1.5-fold and 2-fold stages have increased number of cell corpses due to a defect in cell engulfment (PubMed:20226672). RNAi-mediated knockdown with mig-38 results in enhanced gonad DTC migration (PubMed:22732572). {ECO:0000269|PubMed:19023419, ECO:0000269|PubMed:20226672, ECO:0000269|PubMed:22732572}.