| 176426 |
Q09646 |
SWIC1_CAEEL |
SWI/SNF chromatin-remodeling accessory subunit 1 (Abnormal HSN migration protein 3) |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown at the L1 larval stage reduces brood size (PubMed:26739451). RNAi-mediated knockdown reduces expression of tph-1, which encodes a component of the serotonin synthesis pathway (PubMed:23457234). RNAi-mediated knockdown reduces the level of bed-3 and col-124 mRNAs and increases the level of lin-29 mRNA (PubMed:32417234). Simultaneous knockouts of swsn-2.2 do not survive beyond the L2 larval stage (PubMed:24402584). Simultaneous RNAi-mediated knockdown of swsn-2.2 at the L1 larval stage causes sterility, while at the L3 larval stage, causes embryonic lethality for the progeny (PubMed:26739451). The sterile animals resulting from simultaneous RNAi-mediated knockdown of swsn-2.2 at the L1 larval stage develop smaller germ lines (PubMed:26739451). Simultaneous RNAi-mediated knockdown of swsn-2.2 also results in vulva protrusion and ectopic expression of egl-17 in cells derived from the vulval precursor cells P5.p and P7.p (PubMed:26739451). {ECO:0000269|PubMed:23457234, ECO:0000269|PubMed:24402584, ECO:0000269|PubMed:26739451, ECO:0000269|PubMed:32417234}. |