| 176885 |
O44518 |
CYFIP_CAEEL |
Cytoplasmic FMR1-interacting protein homolog (Gut on exterior protein 2) |
DISRUPTION PHENOTYPE |
Embryonic lethal with cells differentiating, but failing to become organized (PubMed:11877381). The external hypodermal cells fail to spread over and enclose the embryo, but instead cluster on the dorsal side (PubMed:11877381). In one study, animals are viable and there is defective extension of body wall muscle connections or arms towards the ventral nerve cord (PubMed:27123983). In this same study, double knockout with madd-3 results in severe muscle arm extension defects (PubMed:27123983). RNAi-mediated knockdown results in reduced egg laying and in defective endocytosis by oocytes characterized by an accumulation of aggregated yolk protein in the pseudocoelomatic space (PubMed:19798448). {ECO:0000269|PubMed:11877381, ECO:0000269|PubMed:19798448, ECO:0000269|PubMed:27123983}. |