Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 177111
  • Symbol: ced-10
  • Description: Ras-related protein ced-10
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Gene ID Entry Entry Name Protein Name Type Information
177111 Q03206 RAC1_CAEEL Ras-related protein ced-10 (CErac1) (Cell death protein 10) (Cell-corpse engulfment protein ced-10) (Ras-related protein rac-1) DISRUPTION PHENOTYPE In the second generation, there is defective mitotic spindle orientation in the EMS and ABar blastomeres which results in disrupted left-right asymmetry and failure to undergo morphogenesis (PubMed:20126385). Due to defective apoptotic cell clearance, embryos accumulate apoptotic cell corpses (PubMed:20126385). Distal tip cell migratory defects (PubMed:26292279). Double knockout with unc-5 RNAi suppresses the distal tip cell migratory defect in the ced-10 single mutant (PubMed:26292279). {ECO:0000269|PubMed:20126385, ECO:0000269|PubMed:26292279}.