| 177336 |
Q8WQC9 |
DNM1L_CAEEL |
Dynamin-1-like protein drp-1 (EC 3.6.5.5) (Dynamin-related protein drp-1) |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown causes embryonic lethality; onset of lethality is delayed by 12 hr in a caspase ced-3 mutant background (PubMed:10619028). Extremely disorganized gonads, including many nuclei without mitochondria, large clusters of mitochondria without nuclei and cells without either nuclei or mitochondria (PubMed:10619028). Substantial increase in mean lifespan in age-1 mutant background (PubMed:21463460). Substantial increase in mean lifespan in daf-2 mutant (PubMed:21463460). {ECO:0000269|PubMed:10619028, ECO:0000269|PubMed:21463460}. |