Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 177436
  • Symbol: lin-45
  • Description: Raf homolog serine/threonine-protein kinase
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Gene ID Entry Entry Name Protein Name Type Information
177436 Q07292 KRAF1_CAEEL Raf homolog serine/threonine-protein kinase (EC 2.7.11.1) (Abnormal cell lineage protein 45) DISRUPTION PHENOTYPE RNAi-mediated knockdown causes a defect in pachytene progression resulting in a proximal gonad devoid of nuclei. The phenotype is more severe in gck-1 (km15) mutant (PubMed:19826475). RNAi-mediated knockdown in adults decreases lifespan (PubMed:20624915). {ECO:0000269|PubMed:19826475, ECO:0000269|PubMed:20624915}.