Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 177546
  • Symbol: itr-1
  • Description: Inositol 1,4,5-trisphosphate receptor itr-1
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Gene ID Entry Entry Name Protein Name Type Information
177546 Q9Y0A1 ITPR_CAEEL Inositol 1,4,5-trisphosphate receptor itr-1 (IP3 receptor) (IP3R) (InsP3R) (LET-23 fertility effector 1) DISRUPTION PHENOTYPE Disrupted defecation rhythm with reduced pharyngeal pumping in the presence of food resulting in constipation. Disrupted reversal/avoidance response to nose touch. Hermaphrodites display endomitotic oocytes following spermathecal dilation defect and defective ovulation. Loss of male fertility due to defects in turning behavior, spicule insertion and sperm transfer. {ECO:0000269|PubMed:11950942, ECO:0000269|PubMed:15194811, ECO:0000269|PubMed:15958491, ECO:0000269|PubMed:19730689}.