| 177894 |
G5EDB9 |
RPGF_CAEEL |
Rap guanine nucleotide exchange factor (RA-GEF) (PDZ-domain-containing exchange factor) |
DISRUPTION PHENOTYPE |
Beginning in the L2 stage, onward, animals display striking and progressive defects in morphology of the epidermis. Worms show molting defect and exhibit a trail of old cuticle that remains attached to the posterior part of the body. Longitudinal ridges termed alae, which are cuticular structures secreted by lateral hypodermal seam cells, are poorly distinct or interrupted. Sensory rays in males are malformed. Developed a fairly normal gonad but have a strongly reduced fertility. Show uncoordinated movement and an enlarged gut lumen. Died as a 'bag of worms', or alternatively, as a result of a burst vulva. {ECO:0000269|PubMed:15525675}. |