| 177924 |
Q21921 |
SIR2_CAEEL |
NAD-dependent protein deacetylase sir-2.1 (EC 2.3.1.286) (Protein sir-2.1) (Regulatory protein SIR2 homolog 1) |
DISRUPTION PHENOTYPE |
Reduces the longevity-extending effects of nicotinic acid when exposed to 1 mM nicotinic acid (PubMed:24077178). Defective ascaroside-mediated responses with neither ascr#2 nor ascr#3 inducing lifespan extension or conferring thermotolerance (PubMed:23509272). Reduced germ cell apoptosis in the gonadal arms following DNA damage induced by UV-irradiation (PubMed:26598553). RNAi-mediated depletion results in an increase of 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites (PubMed:22393255). {ECO:0000269|PubMed:22393255, ECO:0000269|PubMed:23509272, ECO:0000269|PubMed:24077178, ECO:0000269|PubMed:26598553}. |