Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 178082
  • Symbol: mig-38
  • Description: Abnormal cell migration protein 38
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Gene ID Entry Entry Name Protein Name Type Information
178082 A6ZJ71 MIG38_CAEEL Abnormal cell migration protein 38 DISRUPTION PHENOTYPE Embryonic lethal. RNAi-mediated knockdown results in gonad distal tip cell (DTC) migration defects whereby DTCs do not migrate to the midbody of the hermaphrodite and as a consequence this leads to abnormal gonadal arm formation during gonad morphogenesis. RNAi-mediated knockdown specifically in gonad DTCs also result in a DTC migration defect in which DTCs migrate away from the hermaphrodite midbody on the dorsal basement membrane. RNAi-mediated knockdown in a unc-6 mutant background results in failed gonad DTC migration to the midbody of the hermaphrodite. RNAi-mediated knockdown with ina-1, mig-15 or talin in an rrf-3 mutant background results in enhanced gonad DTC migration. {ECO:0000269|PubMed:22732572}.