| 178167 |
Q19617 |
NLR1_CAEEL |
Neurexin like receptor 1 |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown results in abherrent inx-3-positive gap junction formation along the adjoining membranes of EA and EP endodermal precursor cells at the 16-24 cell stage of embryogenesis, and in adult pharyngeal muscles (PubMed:33238150). The inx-3-positive gap junctions are increased in number, are randomly positioned at irregular intervals on either the EA and EP cells and, although they are along the membrane, they are not on the membrane (PubMed:33238150). Furthermore, F-actin does not accumulate at the gap junction formation plaque in between the EA and EP adjoining membrane, but randomly forms patches along the membrane (PubMed:33238150). RNAi-mediated knockdown does not affect the expression of inx-3 (PubMed:33238150). RNAi-mediated knockdown impairs gap junction function in pharyngeal muscles which disrupts the synchronized muscle contraction between the pharyngeal metacorpus and terminal bulbs and thereby decreases the pharyngeal pumping rate (PubMed:33238150). RNAi-mediated knockdown in the nerve ring results in uncoordinated movements (also known as an unc phenotype), decreased locomotion and defective unc-9-positive gap junction formation and morphology (PubMed:33238150). {ECO:0000269|PubMed:33238150}. |