| 178284 |
G5ECL2 |
SYNJ_CAEEL |
Synaptojanin (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase) (Uncoordinated protein 26) |
DISRUPTION PHENOTYPE |
Viable but small with slow grow and uncoordinated movements (PubMed:10931870, PubMed:21029864). Synaptic vesicles at neuromuscular synapses are reduced, arranged linearly and are dissociated from the synaptic active zone (PubMed:10931870). Several defects in vesicle recycling including accumulation of endocytic pits at the neuromuscular junctions and accumulation of coated vesicles predominantly at synapses of neurons but also near the Golgi in cell bodies of neurons, muscles, hypodermis and gonadal sheath cells (PubMed:10931870). Accumulation of endosome-like compartments in cholinergic and GABA neurons and diffused snb-1/synaptobrevin distribution along the ventral nerve cord (PubMed:10931870). Neurotransmission defects characterized by reduced endogenous frequency of synaptic vesicle fusion, a reduced evoked current amplitude after one stimulation and a faster decline in evoked response caused by multiple responses (PubMed:14622579). Resistant to paralysis induced by Aldicar, an acetylcholinesterase inhibitor which causes acetylcholine accumulation (PubMed:14622579). {ECO:0000269|PubMed:10931870, ECO:0000269|PubMed:14622579, ECO:0000269|PubMed:21029864}. |