| 178350 |
O45228 |
PROD_CAEEL |
Proline dehydrogenase 1, mitochondrial (EC 1.5.5.2) (Proline oxidase) |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown reduces the survival incidence, results in increased bacterial load and reduces ROS production following infection by P.aeruginosa (PubMed:27974198). RNAi-mediated knockdown inhibits the nuclear accumulation of the transcription factor skn-1 and reduces the expression of skn-1 transcriptional targets including gst-4 following infection by P.aeruginosa (PubMed:27974198). RNAi-mediated knockdown suppresses the pro-survival effects of the addition of exogenous proline following infection by P.aeruginosa (PubMed:27974198). {ECO:0000269|PubMed:27974198}. |