| 178821 |
G5EEM0 |
NH114_CAEEL |
Nuclear hormone receptor 114 |
DISRUPTION PHENOTYPE |
No obvious somatic morphological defects in adults (PubMed:23499532). However, shows diet-sensitive sterility arising from germ-cell proliferation defects (PubMed:23499532). Sterile when fed the standard bacterial strain, E.coli B (OP50) as food source, and fertile when maintained on E.coli K-12 strains or bacterial soil isolates (PubMed:23499532). Dietary supplementation of L-tryptophan, but not the D isomer, to E.coli B strains suppresses sterility; this effect requires live bacteria (PubMed:23499532). Sterility when fed E.coli B strain OP50 can be rescued by dietary supplementation of either vitamin B12, methionine or choline (PubMed:33016879). RNAi-mediated knockdown targeted to the intestine, but not the germline, restored almost normal fertility on an E.coli OP50 diet (PubMed:23499532). RNAi-mediated knockdown on a rrf-1 mutant background, in which knockdown occurs mainly in the germline but occurs only weakly in somatic tissues, allowed recovery of a majority (64%) of fertile animals (PubMed:23499532). RNAi-mediated knockdown on an nhr-10 mutant background suppresses expression of acdh-1 (PubMed:33016879). {ECO:0000269|PubMed:23499532, ECO:0000269|PubMed:33016879}. |