Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 179912
  • Symbol: par-1
  • Description: Serine/threonine-protein kinase par-1;non-specific serine/threonine protein kinase
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Gene ID Entry Entry Name Protein Name Type Information
179912 Q9TW45 PAR1_CAEEL Serine/threonine-protein kinase par-1 (EC 2.7.11.1) DISRUPTION PHENOTYPE Maternal effect lethality. Blastomeres cleave synchronously until the fourth or fifth round, when synchrony breaks down. Cells also fail to segregate P granules. Terminal stage embryos fail to produce intestinal cells. Disruption post-hatching results in a protruding vulva, the two mirror-symmetric halves of the vulva fail to join into a single, coherent organ. {ECO:0000269|PubMed:12490197, ECO:0000269|PubMed:3345562}.