Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 180713
  • Symbol: dpy-23
  • Description: AP-2 complex subunit mu
Export (tab separated) Export to Excel
Gene ID Entry Entry Name Protein Name Type Information
180713 P35603 AP2M_CAEEL AP-2 complex subunit mu (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (Mu2-adaptin) (Plasma membrane adaptor AP-2 50 kDa protein) (Protein dumpy-23) DISRUPTION PHENOTYPE Mutants display a squat body statue referred to as a dumpy phenotype and have defective HSN neuronal cell migration (PubMed:18160346). AWB sensory neurons show an expanded ciliary membrane phenotype with enhanced wing cilia and relocalized tub-1 and PtdIns(4,5)P2 to the ciliary base (PubMed:31259686). RNAi-mediated knockdown results in impaired function of the AP-2 complex and accumulation of the wntless homolog mig-14 at the cell membrane (PubMed:18160347). {ECO:0000269|PubMed:18160346, ECO:0000269|PubMed:18160347, ECO:0000269|PubMed:31259686}.