Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 180719
  • Symbol: ncr-1
  • Description: NPC intracellular cholesterol transporter 1 homolog 1
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Gene ID Entry Entry Name Protein Name Type Information
180719 Q19127 NPC1A_CAEEL NPC intracellular cholesterol transporter 1 homolog 1 (Niemann-Pick C1 protein homolog 1) DISRUPTION PHENOTYPE Both ncr-1 single mutant and ncr-1 and ncr-2 double mutants exhibit slow embryonic and larval development, and hyperactive egg-laying behavior (egg-laying constitutive (egl-c) phenotype). Ncr-1 and ncr-2 double mutants inappropriately and transiently form dauer larvae under favorable conditions (dauer-constitutive (daf-c) phenotype). {ECO:0000269|PubMed:10801441}.