Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 180780
  • Symbol: acn-1
  • Description: Inactive angiotensin-converting enzyme-related protein
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Gene ID Entry Entry Name Protein Name Type Information
180780 Q18581 ACN1_CAEEL Inactive angiotensin-converting enzyme-related protein (ACE-like non-metallopeptidase protein 1) DISRUPTION PHENOTYPE RNAi-mediated knockdown results in the extension of mean and maximum lifespan of 21% and 18%, respectively, and increased resistance to oxidative stress caused by paraquat (PubMed:26918946). RNAi-mediated knockdown in a daf-16 mutant background shortens mean and maximum lifespan by 3% and 2%, respectively (PubMed:26918946). RNAi-mediated knockdown in a let-7 mutant background partially suppresses the retarded and supernumerary hypodermal seam cell divisions, retarded alae production and postembryonic lethality (PubMed:28933985). Double RNAi-mediated knockdown with apl-1 in a let-7 mutant phenotype leads to complete suppression of the heterochronic seam cell defects (PubMed:28933985). {ECO:0000269|PubMed:26918946, ECO:0000269|PubMed:28933985}.