Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 180942
  • Symbol: mdl-1
  • Description: BHLH domain-containing protein
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Gene ID Entry Entry Name Protein Name Type Information
180942 G5EG44 MDL1_CAEEL Mad-like protein 1 DISRUPTION PHENOTYPE RNAi-mediated knockdown increases lifespan, which is abolished on an mxl-2 or mml-1 mutant background, or by simultaneous RNAi-mediated knockdown of daf-16 or pha-4 (PubMed:24699255). RNAi-mediated knockdown causes delayed onset of polyglutamine-mediated paralysis (PubMed:24699255). RNAi-mediated knockdown reduces spore levels of the microsporidian pathogen N.parisii during infection, further reduced on an mxl-2 mutant background (PubMed:27402359). {ECO:0000269|PubMed:24699255, ECO:0000269|PubMed:27402359}.