Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 181002
  • Symbol: sox-2
  • Description: HMG box domain-containing protein;Transcription factor sox-2
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Gene ID Entry Entry Name Protein Name Type Information
181002 Q21305 SOX2_CAEEL Transcription factor sox-2 DISRUPTION PHENOTYPE Animals arrest at the first larval stage of development with an unattached pharynx (PubMed:26153233). Able to form neurons, but with defective terminal differentiation of both AWC and AWB olfactory neurons, OLL and IL1 sensory glutamatergic neurons and cholinergic neurons including IL2, URA and URB (PubMed:26153233, PubMed:26341465). RNAi-mediated knockdown results in failed transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron (PubMed:22493276). {ECO:0000269|PubMed:22493276, ECO:0000269|PubMed:26153233, ECO:0000269|PubMed:26341465}.