Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 181051
  • Symbol: zig-4
  • Description: Zwei Ig domain protein zig-4
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Gene ID Entry Entry Name Protein Name Type Information
181051 G5ECB1 ZIG4_CAEEL Zwei Ig domain protein zig-4 (2 Ig domain protein zig-4) DISRUPTION PHENOTYPE At the L1 larval stage, display defects in the positioning of the ventral nerve cord (VNC) axons characterized by axons of embryonically generated PVQ and PVP neurons, but not of RMEV, HSN and AVK neurons, from the left and right VNC drifting into the opposite cord (axon flip-over) (PubMed:11809975, PubMed:19737747). These defects are not enhanced in a zig-3 (tm924) mutant background or in zig-3 (tm924) dig-1 (ky188), zig-3 (tm924) sax-7 (nj48) or zig-3 (tm924) egl-15 (n484) mutant background (PubMed:19737747). In a zig-1, zig-2, zig-3 or zig-5 or zig-8 mutant background, cell body positioning of ASI and ASH head neurons is normal (PubMed:22829780). {ECO:0000269|PubMed:11809975, ECO:0000269|PubMed:19737747, ECO:0000269|PubMed:22829780}.