Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 181321
  • Symbol: vhl-1
  • Description: von Hippel-Lindau tumor suppressor homolog
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Gene ID Entry Entry Name Protein Name Type Information
181321 Q19213 VHL_CAEEL von Hippel-Lindau tumor suppressor homolog DISRUPTION PHENOTYPE Increased mortality induced by B.thuringiensis pore-forming toxins Cry21A and Cry21B (PubMed:20011506). Increased mortality and sensitivity to paralysis induced by enteropathogenic E.coli infection (PubMed:16091039). Increased mortality upon heat stress (PubMed:12686697). RNAi-mediated knockdown causes an enhanced resistance to polyglutamine or amyloid-beta-mediated paralysis and an increase in adult life span. {ECO:0000269|PubMed:12686697, ECO:0000269|PubMed:16091039, ECO:0000269|PubMed:19372390, ECO:0000269|PubMed:20011506}.