| 181432 |
Q19345 |
NHR25_CAEEL |
Nuclear hormone receptor family member nhr-25 |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown results in embryonic or larval lethality in the majority of animals (PubMed:10772806). RNAi-mediated knockdown results in embryos that do not survive due to failed epidermally mediated process of embryo elongation (PubMed:10772806). Of the animals that hatch, larvae display a squat body statue, referred to as a dumpy phenotype, have uncoordinated movements and posterior patterning defects (PubMed:10772806). Larvae also have anterior patterning defects such as kinked or notched noses (PubMed:10772806). Animals that progress to adulthood are sterile and vulvaless (PubMed:10772806). RNAi-mediated knockdown disrupts tail tip morphogenesis resulting in retention of the pointed larval tail tip in 33% of adult males (also known as the Lep phenotype) (PubMed:10772806, PubMed:21408209). Knockdown causes enhanced embryonic lethality on a nob-1 mutant background. {ECO:0000269|PubMed:10772806, ECO:0000269|PubMed:15314147, ECO:0000269|PubMed:21408209}. |