| 187043 |
Q09585 |
APTF1_CAEEL |
Transcription factor aptf-1 (AP2 transcription factor aptf-1) |
DISRUPTION PHENOTYPE |
Animals develop with normal speed and go normally through the molt. They stop feeding for a normal time before each molt, but average nose speed is reduced by only about 10% and unlike wild-type, they are never immobile. The command interneurons AVA and AVE, which control backward movement, are not shut down during sleep-like behavior. Optogenetic channelrhodopsin activation of AIBs, RIBs and RIS interneurons during wake-like behavior using blue light does not trigger acute immobility and cessation of pumping in L1 larvae, instead it causes an increase in mobility (PubMed:24184105). No change in GABAergic function of neurons as unc-25 and the vesicular GABA transporter gene unc-47 are expressed normally. The expression of a neuropeptide gene flp-11 is strongly down-regulated in pretzel-stage embryos and in sleeping L4 larvae (PubMed:26949257). {ECO:0000269|PubMed:24184105, ECO:0000269|PubMed:26949257}. |