Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 189837
  • Symbol: gbb-1
  • Description: G-protein coupled receptors family 3 profile domain-containing protein;Gamma-aminobutyric acid type B receptor subunit 1
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Gene ID Entry Entry Name Protein Name Type Information
189837 H2L0Q3 GABR1_CAEEL Gamma-aminobutyric acid type B receptor subunit 1 DISRUPTION PHENOTYPE Increased lifespan (PubMed:26537867). Increased sensitivity to the acetylcholine esterase inhibitor Aldicarb, which results in accelerated paralysis likely due to enhanced acetylcholine release by ventral cord neurons and enhanced depolarization of muscles on one side of the body (PubMed:18614679). Double knockout with gbb-2 also results in increased sensitivity to Aldicarb and accelerated paralysis, but in addition results in irregular locomotory behavior characterized by increased speed of locomotion, decreased turning frequency, reduced rate of reversals, and an increased maximal distance covered in a 40 second interval (PubMed:18614679). Double knockout with the GABA(A) receptor unc-49 results in body elongation defects in response to induced GABA release of GABAergic motor neurons (PubMed:21613582). {ECO:0000269|PubMed:18614679, ECO:0000269|PubMed:21613582, ECO:0000269|PubMed:26537867}.