| 191240 |
G5ECB2 |
GABR2_CAEEL |
Gamma-aminobutyric acid type B receptor subunit 2 |
DISRUPTION PHENOTYPE |
Increased sensitivity to the acetylcholine esterase inhibitor Aldicarb, which results in accelerated paralysis likely due to enhanced acetylcholine release by ventral cord neurons and enhanced depolarization of muscles on one side of the body (PubMed:18614679). Increased locomotion and body curvature (deeper bends) in response to induced GABA release of GABAergic motor neurons, which in wild-type animals results in acute body relaxation (PubMed:21613582). Double knockout with gbb-1 also results in increased sensitivity to Aldicarb and accelerated paralysis, but in addition results in irregular locomotory behavior characterized by increased speed of locomotion, decreased turning frequency, reduced rate of reversals, and an increased maximal distance covered in a 40 second interval (PubMed:18614679). Double knockout with the muscarinic acetylcholine receptor gar-2 results in a slight increase in sensitivity to Aldicarb and accelerated paralysis 50 minutes following exposure to Aldicarb as compared to the gar-2 and gbb-2 single mutants (PubMed:18614679). Double knockout with the GABA(A) receptor unc-49 results in body elongation defects in response to induced GABA release of GABAergic motor neurons (PubMed:21613582). {ECO:0000269|PubMed:18614679, ECO:0000269|PubMed:21613582}. |