Mine Disruption Phenotype

Gene Info

  • Species: Worm (Caenorhabditis elegans)
  • GeneID: 192088
  • Symbol: zig-3
  • Description: Zwei Ig domain protein zig-3
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Gene ID Entry Entry Name Protein Name Type Information
192088 G5EEY6 ZIG3_CAEEL Zwei Ig domain protein zig-3 (2 Ig domain protein zig-3) DISRUPTION PHENOTYPE At the L1 larval stage, display defects in the positioning of the ventral nerve cord (VNC) axons characterized by axons of PVQ and PVP neurons, but not of RMEV, HSN and AVK neurons, drifting into the opposite VNC side (axon flip-over) (PubMed:19737747). These defects are not enhanced in a zig-4 (gk34) mutant background or in zig-4 (gk34) dig-1 (ky188), zig-4 (gk34) sax-7 (nj48) or zig-4 (gk34) egl-15 (n484) mutant background (PubMed:19737747). In a zig-1, zig-2, zig-4 or zig-5 or zig-8 mutant background, cell body positioning of ASI and ASH head neurons is normal (PubMed:22829780). {ECO:0000269|PubMed:19737747, ECO:0000269|PubMed:22829780}.