| 3565793 |
Q9N3Q4 |
ATM_CAEEL |
Serine/threonine-protein kinase ATM (EC 2.7.11.1) |
DISRUPTION PHENOTYPE |
Increased sensitivity to ionizing radiation with reduced survival compared to wild-type animals. Loss of induction of apoptosis following UV-C or ionizing radiation treatment but no effect on apoptotic response induced by X-ray exposure. Low brood size, reduced viability and sterility, appearance of a high-incidence-of-males (Him) phenotype, and reduced chromosome number due to chromosome fusions. {ECO:0000269|PubMed:17347667, ECO:0000269|PubMed:22350747}. |