| 31037 |
Q9V410 |
LZTR1_DROME |
Leucine-zipper-like transcriptional regulator 1 homolog |
DISRUPTION PHENOTYPE |
Flies are viable but most wings show wing vein defects characterized by extra veins and vein tissue, which are caused by an increase of Ras-MAPK signaling (PubMed:30442766, PubMed:32339168). Decreases sleep with night-time sleep-fragmentation patterns, primarily during the second part of the night (PubMed:32339168). RNAi-mediated knockdown in neurons of males results in reduced total sleep in combination with decreased locomotor activity, increased Ras-MAPK signaling and altered metabolism including reduced glycogen levels and increased levels of triglycerides (PubMed:32339168). RNAi- mediated knockdown in GABAA-receptor-expressing neurons causes a shortening of sleep bouts and an increase in their number during night, with an effect size similar to that seen with pan-neuronal knockdown (PubMed:32339168). RNAi-mediated knockdown in peripheral class-IV dendritic arborization neurons does not cause increased proliferation in the nervous system (PubMed:32339168). Adult-specific RNAi-mediated neuronal knockdown decreases night-time sleep compared to controls and caused an increased number of short sleep bouts during the night (PubMed:32339168). RNAi-mediated knockdown of in GABAB-receptor-expressing neurons or PDF-expressing clock neurons-had no significant effect on night-time sleep-bout number or duration (PubMed:32339168). Simultaneous knockdown of Lztr1 and Nf1 reduces total night-time sleep, increases night-time sleep fragmentation and activates the Ras pathway similarly to single knockdown (PubMed:32339168). {ECO:0000269|PubMed:30442766, ECO:0000269|PubMed:32339168}. |