| 31271 |
P10090 |
WHITE_DROME |
Protein white (EC 7.6.2.-) (EC 7.6.2.6) (ATP-binding cassette transporter sub-family G member white) (Broad substrate specificity ATP-binding cassette transporter white) |
DISRUPTION PHENOTYPE |
Eyes are white due to a defect in color pigment production (PubMed:18310115, PubMed:33820991). Malpighian tubules appear clear or white (PubMed:18310115, PubMed:29367274). Loss of st/scarlet protein in the pigment cells and retinula cells of the compound eye (PubMed:11294610). Transport of cGMP, but not cAMP, is inhibited in Malpighian tubules; however, basal fluid transport rates or rates stimulated by cGMP in the tubules are normal (PubMed:18310115). In Malpighian tubules, uptake of guanine, xanthine and riboflavin is impaired while uptake of hypoxanthine, guanosine and adenine is not affected (PubMed:117796). In Malpighian tubules, kynurenine and tryptophan uptake is impaired; however, incorporation of tryptophan into proteins is not affected (PubMed:6788034, PubMed:812484). In pupal eyes, kynurenine uptake is impaired (PubMed:812484). In the head, 50% reduction in histamine levels, 60% reduction in dopamine levels and 32% reduction in serotonin (5-HT) levels (PubMed:18931318). Specifically, histamine levels are reduced in the retina, the retina lamina and the central brain (PubMed:18931318). In addition, in lamina photoreceptor terminals R1-R6, numbers of synaptic vesicles and capitate projections, which are sites of endocytosis of vesicle membrane, are reduced (PubMed:18931318). In young and old flies, reduces the levels of several metabolites, including tryptophan, kynurenine, kynurenic acid, 3-hydroxykynurenine, guanosine, xanthine, riboflavin and tetrahydrofolate, and increases the levels of guanine (PubMed:33820991). Inhibits aging-induced intestinal stem cell proliferation (PubMed:33820991). 3-fold reduction in Malpighian tubule zinc stores (PubMed:29367274). Severe reduction of copulation success and reduced courting activities in males (PubMed:28794482). RNAi-mediated knockdown in central nervous system causes a delay in locomotor recovery from anoxia with no effect on eye pigmentation (PubMed:27029736). RNAi-mediated knockdown in serotonergic neurons, causes a delay in locomotor recovery from anoxia (PubMed:27029736). {ECO:0000269|PubMed:11294610, ECO:0000269|PubMed:117796, ECO:0000269|PubMed:18310115, ECO:0000269|PubMed:18931318, ECO:0000269|PubMed:27029736, ECO:0000269|PubMed:28794482, ECO:0000269|PubMed:29367274, ECO:0000269|PubMed:33820991, ECO:0000269|PubMed:6788034, ECO:0000269|PubMed:812484}. |