| 31581 |
Q7YU24 |
MARF_DROME |
Transmembrane GTPase Marf (EC 3.6.5.-) (Mitochondrial assembly regulatory factor) (Mitofusin) |
DISRUPTION PHENOTYPE |
Lethal at the early larval stage (L1/L2); mitochondria are fragmented and mitochondrial respiration is impaired (PubMed:26214738). RNAi-mediated knockdown is also lethal (PubMed:20869429). RNAi-mediated knockdown in specific tissues such as cardiomyocytes, muscles and larval neurons produces various phenotypes resulting from adherent, dysfunctional mitochondria (PubMed:18799731, PubMed:20869429, PubMed:22396657, PubMed:24192653). Mitochondria display characteristics such as abnormal cristae, fragmentation, elongation, decreased DNA content, increased ROS and depolarization (PubMed:20869429, PubMed:20194754, PubMed:22396657, PubMed:24192653). Mitochondria in larval muscles display increased mitochondrial flux and net velocity in both anterograde and retrograde directions (PubMed:20194754). {ECO:0000269|PubMed:18799731, ECO:0000269|PubMed:20194754, ECO:0000269|PubMed:20869429, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:24192653, ECO:0000269|PubMed:26214738}. |