| 32522 |
X2JDY8 |
RHGF_DROME |
Rho GTPase-activating protein Graf (GTPase regulator associated with focal adhesion kinase) |
DISRUPTION PHENOTYPE |
RNAi-mediated knockdown in embryos is lethal at 24 hr, likely due to defective cellularization (PubMed:33835025). During cellularization, the F-actin network at the base of the furrow canal is unorganized, the furrow tips contain wavy edges and there is a loss of contact between adjacent furrow tips (PubMed:33835025). Actomyosin ring constriction is enhanced, and the nuclei have a bottleneck appearance likely due to premature constriction at the furrow canal tip during the mid cellularization stage (PubMed:33835025). Another study reports that flies are viable and fertile (PubMed:28993397). RNAi-mediated knockdown in the alpha/beta neurons of the adult mushroom body (MB), results in abnormal crossing of the MB beta lobe over the brain midline (PubMed:33892766). {ECO:0000269|PubMed:28993397, ECO:0000269|PubMed:33835025, ECO:0000269|PubMed:33892766}. |